Adaptation of influenza A/Mallard/Potsdam/178-4/83 H2N2 virus in Japanese quail leads to infection and transmission in chickens.
Identifieur interne : 001394 ( Main/Exploration ); précédent : 001393; suivant : 001395Adaptation of influenza A/Mallard/Potsdam/178-4/83 H2N2 virus in Japanese quail leads to infection and transmission in chickens.
Auteurs : E M Sorrell [États-Unis] ; D R PerezSource :
- Avian diseases [ 0005-2086 ] ; 2007.
Descripteurs français
- KwdFr :
- Adaptation physiologique, Animaux, Appareil respiratoire (virologie), Coturnix (virologie), Grippe chez les oiseaux (transmission), Grippe chez les oiseaux (virologie), Poulets (virologie), Réplication virale, Sous-type H2N2 du virus de la grippe A (), Sous-type H2N2 du virus de la grippe A (physiologie).
- MESH :
English descriptors
- KwdEn :
- MESH :
- classification : Influenza A Virus, H2N2 Subtype.
- physiology : Influenza A Virus, H2N2 Subtype.
- transmission : Influenza in Birds.
- virology : Chickens, Coturnix, Influenza in Birds, Respiratory System.
- Adaptation, Physiological, Animals, Virus Replication.
Abstract
To assess the potential of quail as an intermediate host of avian influenza, we tested the influenza A/Mallard/ Potsdam/178-4/83 (H2N2) virus to determine whether through adaptation a mallard strain can replicate and transmit in quail, as well as other terrestrial birds. After five serial passages of lung homogenate a virus arose that replicated and transmitted directly to contact cage mates. To test whether adaptation in quail led to interspecies transmission, white leghorn chickens were infected with the wild-type (mall/178) and quail-adapted (qa-mall/178) viruses. The results show that mall/178 H2N2 does not establish an infection in chickens nor does it transmit, while qa-mall/178 H2N2 infects and transmits to contact chickens causing clinical signs like depression and diarrhea. Completed sequences indicate six amino acid changes spanning four genes, PB2, PB1, HA, and NP, suggesting that the internal genes play a role in host adaptation. Further adaptation of qa-mall/178 in white leghorn chickens created a virus that replicated more efficiently in the upper and lower respiratory tract. Sequence analysis of the chicken-adapted virus points to a deletion in the neuraminidase stalk region.
DOI: 10.1637/7538-032906R.1
PubMed: 17494563
Affiliations:
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Le document en format XML
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Drive, College Park, MD 20742</wicri:regionArea><orgName type="university">Université du Maryland</orgName><placeName><settlement type="city">College Park (Maryland)</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Perez, D R" sort="Perez, D R" uniqKey="Perez D" first="D R" last="Perez">D R Perez</name></author></analytic><series><title level="j">Avian diseases</title><idno type="ISSN">0005-2086</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological</term><term>Animals</term><term>Chickens (virology)</term><term>Coturnix (virology)</term><term>Influenza A Virus, H2N2 Subtype (classification)</term><term>Influenza A Virus, H2N2 Subtype (physiology)</term><term>Influenza in Birds (transmission)</term><term>Influenza in Birds (virology)</term><term>Respiratory System 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scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Coturnix</term><term>Grippe chez les oiseaux</term><term>Poulets</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chickens</term><term>Coturnix</term><term>Influenza in Birds</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Physiological</term><term>Animals</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adaptation physiologique</term><term>Animaux</term><term>Grippe chez les oiseaux</term><term>Réplication virale</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the potential of quail as an intermediate host of avian influenza, we tested the influenza A/Mallard/ Potsdam/178-4/83 (H2N2) virus to determine whether through adaptation a mallard strain can replicate and transmit in quail, as well as other terrestrial birds. After five serial passages of lung homogenate a virus arose that replicated and transmitted directly to contact cage mates. To test whether adaptation in quail led to interspecies transmission, white leghorn chickens were infected with the wild-type (mall/178) and quail-adapted (qa-mall/178) viruses. The results show that mall/178 H2N2 does not establish an infection in chickens nor does it transmit, while qa-mall/178 H2N2 infects and transmits to contact chickens causing clinical signs like depression and diarrhea. Completed sequences indicate six amino acid changes spanning four genes, PB2, PB1, HA, and NP, suggesting that the internal genes play a role in host adaptation. Further adaptation of qa-mall/178 in white leghorn chickens created a virus that replicated more efficiently in the upper and lower respiratory tract. Sequence analysis of the chicken-adapted virus points to a deletion in the neuraminidase stalk region.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>College Park (Maryland)</li></settlement><orgName><li>Université du Maryland</li></orgName></list><tree><noCountry><name sortKey="Perez, D R" sort="Perez, D R" uniqKey="Perez D" first="D R" last="Perez">D R Perez</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Sorrell, E M" sort="Sorrell, E M" uniqKey="Sorrell E" first="E M" last="Sorrell">E M Sorrell</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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